| CAS No.: | 86088-83-7 |
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| Formula: | / |
| EINECS: | 289-149-2 |
| Environmental Protection: | No |
| Certification: | ISO9001 |
| Color: | White |
| Samples: |
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| Customization: |
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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
| Product Name: | FIBRONECTIN |
| Synonyms: | Anti-Fibronectin 1, C-Terminal antibody produced in rabbit;fibronectin 1;FINC;Fibronectin solution from human fibroblasts ;Fibronectin, bovine, stabilized soln.;HFN;FIBRONECTIN (MS PLASMA);FIBRONECTIN, RAT |
| CAS: | 86088-83-7 |
| MF: | NULL |
| MW: | 0 |
| EINECS: | 289-149-2 |
| Product Categories: | |
| Mol File: | Mol File |
| storage temp. | -20°C |
| solubility | H2O: 1 mg/mL at 37 °C Store reconstituted solution in working aliquots at -20°C or lower. |
| form | solution |
| Water Solubility | Miscible with water. |
| Hazard Codes | B |
| WGK Germany | 3 |
| F | 10-21 |
| Uses | fibronectin (hydrolyzed) is a humectant and moisturizing agent for skin creams and lotions. |
| Uses | fibronectin is a cosmetic ingredient described as a surface protective agent with a moisturizing and protective effect. Produced by many types of cells, fibronectin is a glycoprotein and an important component of the skin's basal layer. Research suggests fibronectin plays a significant role in maintaining a healthy basal layer. Fibronectin's function in the skin is to strengthen the attachments among collagen and elastin fibers, fibroblasts, and other cells in the dermis with connective tissues. Its presence may also be important to cell growth. There is some evidence that fibronectin may act as a cell regenerator by reversing abnormal cell formation and growth. It constitutes 1 to 3 percent of the total cellular protein of fibroblasts. |
| Uses | Fibronectin solution from human fibroblasts is used for the following applications:
Fibronectin from human plasma can be used with epithelial cells, mesenchymal cells, neuronal cells, fibroblasts, neural crest cells, and endothelial cells. It is recommended for use as a cell culture substratum at 1-5 μg/cm2 or 0.5-50 μg/mL. The optimal concentration does depend on cell type as well as the application and research objectives. |
| General Description | Native fibronectin purified from human plasma. Effective agent for promoting attachment of cells to commonly-used culture substrates. |
| Biochem/physiol Actions | Fibronectin is a high molecular mass extracellular matrix glycoprotein involved in many cellular processes, including tissue repair, embryogenesis, blood clotting, cell migration/adhesion, and embryogenesis and development. It is used in vitro as a substrate to enhance adherence and proliferation of many cell types. It has the capacity to bind to macromolecules such as collagen, fibrin, glycosaminoglycans, and Clq, apart from some bacteria. |
| Purification Methods | This glycoprotein contains 5-12% of carbohydrate. It has been purified by glycine fractionation and DEAE-cellulose chromatography. This material is dissolved in 0.25M Tris-phosphate buffer pH 7.0, diluted to 20% and glycine added gradually till 2.1M when the temperature falls to below 15o. The precipitate contains mainly fibrinogen. The supernatant is discarded, and the precipitate is treated with an equal volume of H2O, cooled (to 0o) and precipitated by adding EtOH to 16% (v/v) at -4o. The precipitate contains some CI (Cold Insoluble) globulin, fibronectin and small quantities of other proteins. To remove these the precipitate is dissolved in 0.25M Tris-phosphate buffer (pH 7.0) ca 0.5% and purified by DEAE-cellulose chromatography after diluting the buffer to 0.05M buffer. [Morrison et al. J Am Chem Soc 70 3103 1948, Mosesson & Umfleet J Biol Chem 245 5728 1970, Mosesson & Amrani Blood 56 145 1980, Akiyama & Yamada Adv Enzymol 59 51 1987.] |
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