4′ -Methoxyacetophenone; PARA Methoxyl Acetophenone; CAS100-06-1

• CAS No.: 100-06-1
• Formula: C9h10o2
• EINECS: 202-815-9
• Appearance: Crystal
• Type: Pharmaceutical Intermediates
• Quality: Refined
• Colour: White
• Samples: Available
• Purity: 99%
• Certificates: ISO9001/SGS
• Package: 1kg/5kg/10kg/25kg
• Stocks: in Stock
• Lead Time: 5-7 Working Days
• Shelf Life: 2-3 Years
• Site Audit: Available
• Transport: Air/Express/Sea
• MOQ: 10g
• Transport Package: Drum/Bottle/Bags
• Trademark: Yunbang
• Origin: China

Product Description

4′-Methoxyacetophenone;Para Methoxyl Acetophenone;CAS100-06-1
 

 

4'-Methoxyacetophenone Chemical Properties

Melting point	36-38 °C (lit.)
Boiling point	152-154 °C/26 mmHg (lit.)
density	1.08
FEMA	2005 | ACETANISOLE
refractive index	1.5470 (estimate)
Fp	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	H2O: soluble2.474g/L at 20°C
form	Crystals or Crystalline Powder
color	White
Water Solubility	insoluble
Sensitive	Light Sensitive
JECFA Number	810
BRN	742313
InChIKey	NTPLXRHDUXRPNE-UHFFFAOYSA-N
CAS DataBase Reference	100-06-1(CAS DataBase Reference)
NIST Chemistry Reference	Acetophenone, 4'-methoxy-(100-06-1)
EPA Substance Registry System	4'-Methoxyacetophenone (100-06-1)

Safety Information

4'-Methoxyacetophenone Usage And Synthesis

Identification	CAS.No.:  100-06-1  FL.No.:  7.038 FEMA.No.:  2005 NAS.No.:  2005 CoE.No.:  570 EINECS.No.:  202-815-9  JECFA.No.:  810
Description	Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors.
Regulatory Status	CoE: Approved. Bev.: 10 ppm; Food: 20 ppm FDA: 21 CFR 172.515 FDA (other): n/a JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2001).
Usage	Reported uses (ppm): (FEMA, 1994) Food Category  Usual  Max.  Alcoholic.beverages  0.0001 0.0001 Baked.goods  1.5 2 Chewing.gum  110 110 Frozen.dairy  1 2 Gelatins,.puddings  0.2 0.2 Hard.candy  278.3 335 Meat.products  100 100 Nonalcoholic.beverages  7.8 150 Soft.candy  2.1 31
Natural occurrence	Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).
Chemical Properties	WHITE CRYSTALS OR CRYSTALLINE POWDER
Chemical Properties	4-Methoxyacetophenone occurs in anise oil. It forms white crystals (mp 38°C) with a sweet odor, reminiscent of hawthorn. 4-Methoxyacetophenone is prepared by Friedel-Crafts acetylation of ani sole. A modern process uses ??-zeolites as Friedel-Crafts catalysts in combination with a continuous flow technology. 4-Methoxyacetophenone is used in soap perfumes
Chemical Properties	Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors
Occurrence	Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).
Uses	4'-Methoxyacetophenone is a solid, pale yellow flavoring agent with a hawthornlike odor. It is soluble in most fixed oils and prop ylene glycol, and it is insoluble in glycerin and mineral oil. It is obtained by chemical synthesis. This flavoring substance or its adjuvant may be safely used in food in the minimum quantity required to produce its intended flavor. It can be used alone or in combination with other flavoring substances or adjuvants. It is also termed p-methoxyacetophenone.
Uses	Perfumery (for floral odors), flavoring.
Definition	ChEBI: A member of the class of acetophenones that is acetophenone substituted by a methoxy group at position 4.
Preparation	From aniso le and ac etyl chlor ide in the presence of aluminum chloride and carbon disulfide; from anis ole and acetic acid in the presence of b oron trif luoride.
Taste threshold values	Taste characteristics at 10 ppm: sweet, anisic, fruity, cherry with powdery vanilla nuances.
Synthesis Reference(s)	The Journal of Organic Chemistry, 46, p. 5414, 1981 DOI: 10.1021/jo00339a036 Synthetic Communications, 26, p. 291, 1996 DOI: 10.1080/00397919608003617 Tetrahedron Letters, 35, p. 9471, 1994 DOI: 10.1016/S0040-4039(00)78574-1
Safety Profile	Moderately toxic by ingestion. Human systemic effects by inhalation: pulse rate increase without fall in blood pressure and blood pressure elevation. A skin irritant. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
Purification Methods	Crystallise the ketone from diethyl ether/pet ether. [Beilstein 8 IV 340.]

 

Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products.
We can perform -100°C to 300°C reaction.

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.

Our goal : To achieve the integrated upgrade of Pharmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating our brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.