Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5

Product Details
Customization: Available
CAS No.: 19172-47-5
Formula: C14h14o2p2s4
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  • Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5
  • Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5
  • Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5
  • Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5
  • Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5
  • Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5
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Basic Info.

EINECS
242-855-4
Appearance
Powder
Type
Pharmaceutical Intermediates
Quality
Refined
Colour
Yellow
Samples
Available
Purity
99%
Certificates
ISO9001/SGS
Package
1kg/5kg/10kg/25kg
Stocks
in Stock
Lead Time
5-7 Working Days
Shelf Life
2-3 Years
Site Audit
Available
Transport
Air/Express/Sea
MOQ
10g
Transport Package
Drum/Bottle/Bags
Trademark
Yunbang
Origin
China

Product Description

Lawesson's Reagent;2,4-Bisthiolato-2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphospha(V)cyclobutane-2,4-diylium;CAS19172-47-5

Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5
 
Lawesson's Reagent Chemical Properties
Melting point  228-230 °C(lit.)
Boiling point  525.8±60.0 °C(Predicted)
density  1.48±0.1 g/cm3(Predicted)
storage temp.  Inert atmosphere,2-8°C
form  Powder
color  White to almost white
Water Solubility  Decomposition
Sensitive  Moisture Sensitive
Merck  14,5391
BRN  1024888
CAS DataBase Reference 19172-47-5(CAS DataBase Reference)
EPA Substance Registry System 1,3,2,4-Dithiadiphosphetane, 2,4-bis(4-methoxyphenyl)-, 2,4-disulfide (19172-47-5)
 
Safety Information
Hazard Codes  Xn-F,Xi,Xn,F
Risk Statements  20/21/22-15/29-37
Safety Statements  8-43-36/37-22-38-7/8
RIDADR  3278
WGK Germany  3
13-21
TSCA  Yes
HazardClass  4.3
PackingGroup  III
HS Code  29349990
 
Lawesson's Reagent Usage And Synthesis
description Lawesson's reagent, also known as Lloyd's reagent, is a commonly used chemical reagent in the preparation of organic sulfur compounds. At room temperature under normal pressure, it appears as the solid yellow powder with a strong smell of rotten. In 1956, it was first successfully produced by the reaction between arene and tetraphosphorus decasulfide. The Swedish chemist Sven-Olov Lawesson has carefully studied its reaction with organic compounds, so that its application has been greatly promoted, so the name also derived. The molecule of the Lawesson's reagent contains the four-membered ring structure alternately composed of sulfur and phosphorus.
Upon being heated, it undergoes depolymerization, generating two molecules of unstable ylide (R-PS2), which are the major reactive intermediates. Upon application of the Lawesson's reagents with two different substitution groups for reaction, it has been observed of molecules with substituent group exchanged with each other in the 31 NMR spectrum of the product, confirming the existence of the intermediates, R-PS2.
Lawesson's reagent is an oxygen-sulfur exchange reagent with the most common application being for the preparation of thioamides and converting carbonyl compounds into sulfur carbonyl compounds. The reacted substrates can include ketone, ester, lactone, amide, lactam, and quinone. The electron-rich carbonyl groups are easier to react. Upon reaction with α, β-unsaturated aldehydes and ketones, the double bond is not affected.
reactions 1, aliphatic, aromatic and heterocyclic aromatic amide can have reaction with Lawson well. Tetra-sulfide is also commonly used sulfide reagents, but its usage can sometimes result in amide decomposition into nitrile and hydrogen sulfide, so that the reaction yield is reduced.
2. A mixture of silver perchlorat e and Lawson's reagent can be used as an oxygen-reactive Lewis acid to catalyze the Diels-Alder reaction of dienes with α, β-unsaturated aldehydes.
3, 4-dione is cyclized to thiophen e upon reaction with a Lawesson's reagent. It is also possible to react with tetrasulfide pentasulfide, but the reaction requires a higher temperature.
4, Lawesson's reagent can react with sulfoxide to generate thio products, and then generate sulfur ether through desulfurization. Therefore, it can be used as the reducing agent of sulfoxide.
5, the yield of the reaction between the Lawesson's reagent and the amide with the adjacent position of the benzene ring connecting with hydroxyl or amino group is not high, because of generating the following by-products. The reaction can be used for the preparation of thio-monoalkylphosphonate compounds.
similar products Many compounds similar to Lawesson's reagent compounds have been prepared. They are easier to use than the Lawesson's reagent with the reaction conditions being mild and the yield being relatively high. When the methoxyphenyl group is substituted with an alkyl group such as methyl, ethyl, isopropyl or butyl, the generated reagent is called Davy reagent (DR). When the substituent group is phenylthio group, the generated reagent is referred to Japanese reagent (JR). When the substituent group is p-phenoxyphenyl group, it is referred to as the Belleau reagent (BR), All of them can be prepared from the reaction between the corresponding mercaptans and tetrasulfide pentasulfide.
Uses Vulcanizing agents, which have recently been used to generate tropothione in situ at room temperature and capture the sulfur hybrid reagents with dienophiles.
Chemical Properties light yellow to beige powder
Uses Thiation reagent.
 
Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5
 
Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5Lawesson′ S Reagent; 2, 4-Bisthiolato-2, 4-Bis (4-methoxyphenyl) -1, 3-Dithia-2, 4-Diphospha (V) Cyclobutane-2, 4-Diylium; CAS 19172-47-5
Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products.
We can perform -100°C to 300°C reaction.

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.

Our goal : To achieve the integrated upgrade of Pharmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating our brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.

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