| CAS No.: | 828-51-3 |
|---|---|
| Formula: | C11h16o2 |
| EINECS: | 212-584-6 |
| Appearance: | Powder |
| Type: | Pharmaceutical Intermediates |
| Quality: | Refined |
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| 1-Adamantanecarboxylic acid Basic information |
| Product Name: | 1-Adamantanecarboxylic acid |
| Synonyms: | 1-Adamantanecarboxylic;Adamantane-1-carboxylic acid 99%;1-ADMANTANE CARBOXYLIC ACID;1-Adamantane-1-carboxylic acid;1-Adamantanecarboxylic acid ,99%;3-adamantanecarboxylicacid;adamantanecarboxylic acid;Adamantoic acid |
| CAS: | 828-51-3 |
| MF: | C11H16O2 |
| MW: | 180.24 |
| EINECS: | 212-584-6 |
| Product Categories: | C11 to C12;Carbonyl Compounds;Organic acids;Adamantanes;Carboxylic Acids |
| Mol File: | 828-51-3.mol |
| 1-Adamantanecarboxylic acid Chemical Properties |
| Melting point | 172-174 °C (lit.) |
| Boiling point | 253.08°C (rough estimate) |
| density | 0.9976 (rough estimate) |
| refractive index | 1.4910 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 4.86±0.20(Predicted) |
| color | White to off-white |
| Water Solubility | Insoluble in water. Solubility in methanole gives very faint turbidity. Soluble in ethanol, chloroforme, and dichloromethanei. |
| BRN | 1910637 |
| InChIKey | JIMXXGFJRDUSRO-UHFFFAOYSA-N |
| CAS DataBase Reference | 828-51-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Adamantane-1-carboxylic acid(828-51-3) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | AU4452200 |
| Hazard Note | Irritant |
| HS Code | 29162000 |
| 1-Adamantanecarboxylic acid Usage And Synthesis |
| Chemical Properties | white to off-white crystalline powder |
| Uses | Adamantoic Acid is an inhibitor of chorismate mutase activity and hydroxyphenylpyruvate synthase. It inhibits TTR conformational changes facilitating amyloid fibril formation. |
| Synthesis Reference(s) | Synthetic Communications, 18, p. 545, 1988 DOI: 10.1080/00397918808060749 |
| Purification Methods | Possible impurities are trimethylacetic acid and C9 and C13 acids. Dissolve 15g of the acid in CCl4 (300mL) and shake with 110mL of 15N aqueous NH3 whereby the ammonium salt separates and is collected. Acid impurities form soluble ammonium salts. The salt is washed with cold Me2CO (20mL) and suspended in H2O (250mL). This is treated with 12N HCl and extracted with CHCl3 (100mL). The dried (Na2SO4) extract was evaporated and the residue was recrystallised from a mixture of MeOH (30mL) and H2O (ca 10mL) to give the pure acid (10-11g). [Koch & Haaf Org Synth Coll Vol V 20 1973.] It was also recrystallised from absolute EtOH and dried under vacuum at 100o. Alternatively, the acid (5g) is refluxed for 2hours with 15mL of MeOH and 2mL of 98% H2SO4 (cool when mixing this solution). Pour into 10 volumes of H2O and extract with the minimum volume of CHCl3 to give clear separation of phases. The extract is washed with H2O, dried (CaCl2) and distilled. The methyl ester is collected at 77-79o/1mm, m 38-39o. The ester is hydrolysed with the calculated amount of N KOH and refluxed until clear. Acidification with HCl provides the pure acid with 90% recovery. The amide crystallises from cyclohexanei, m 189o. [Stetter et al. Chem Ber 92 1629 1959.] [Beilstein 9 IV 253.] |
| 1-Adamantanecarboxylic acid Preparation Products And Raw materials |
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