| Customization: | Available |
|---|---|
| CAS No.: | 9001-73-4 |
| Formula: | / |
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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".Papain is a proteolytic enzyme obtained from the latex of the papaya fruit (Carica papaya). It is a cysteine protease that has the ability to break down peptide bonds in proteins. Papain is commonly used in various applications, including meat tenderization, brewing, and the food industry as a digestive aid. It is also utilized in the production of cheese, in the pharmaceutical industry for its anti-inflammatory properties, and in the cosmetic industry for its exfoliating effects. Papain has been studied for its potential medical applications, including wound healing and anti-cancer properties.
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | Papain |
| Synonyms: | Papain Coarse-enzyme;Papain;Velardon;Vermizym;Papain, for biochemistry;papain from carica papaya;papain from papaya latex;PAPAIN,POWDER,PURIFIED |
| CAS: | 9001-73-4 |
| MF: | C9H14N4O3 |
| MW: | 226.23246 |
| EINECS: | 232-627-2 |
| Mol File: | 9001-73-4.mol |
| Fp | 29 °C |
| storage temp. | 2-8°C |
| solubility | H2O: soluble1.2mg/mL |
| form | lyophilized powder |
| color | almost white |
| Water Solubility | Soluble in water, insoluble in most organic solvents. |
| Merck | 7016 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16) |
| InChIKey | CQOVPNPJLQNMDC-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C(NC(=O)CCN)CC1NC=NC=1 |
| EPA Substance Registry System | Papain (9001-73-4) |
| Hazard Codes | Xn |
| Risk Statements | 42/43-42-36/37/38-20/21/22-10 |
| Safety Statements | 36-36/37-26-24-22-45-23-36/37/39 |
| WGK Germany | 3 |
| RTECS | RU4950000 |
| TSCA | Yes |
| HS Code | 35079090 |
| Toxicity | TDLo orl-man: 71 mg/kg:GIT JCGADC 9,127,87 |
| Chemical Properties | cream to light brown powder |
| Originator | Papain,Green Cross ,Japan,1969 |
| Uses | Papain may cause allergic manifestation .Person handling this material should be protected against inhalation of dust and contact with the skin or eyes. |
| Uses | For tenderizing meats; for clearing beverages; for bating skins. |
| Uses | papain is a papaya enzyme able to dissolve keratin. Papain is used in face masks and peeling lotions as a very gentle exfoliant. It can be irritating to the skin but less so than bromelin, a similar enzyme found in pineapples and also used in cosmetics. It is considered a non-comedogenic raw material. |
| Uses | Papain is a tenderizer that is a protein-digesting enzyme obtained from the papaya fruit. the enzyme, used in a patented process, is injected into the circulatory system of the live animal and is activated by the heat of cooking to break down the protein, thus tenderizing the beef. the enzyme is inactivated by stomach acids. |
| Definition | papain: A protein-digesting enzymeoccurring in the fruit of the West Indianpapaya tree (Carica papaya). It isused as a digestant and in the manufactureof meat tenderizers. |
| Application | Papain (EC 3.4.22.2) is a protease derived from the latex portion of the papaya plant ( Carica papaya ), and is gathered by scoring the surface of the mature, unripe fruit, after which the latex is collected and dried (Schwimmer, 1981) . Drying can occur by one of several methods: sun, oven, or spray drying; end products having the highest activity are obtained by spray drying. Papain has broad-spectrum enzyme activity over a wide pH and temperature range, and it cleaves at basic amino acids or those having large hydrophobic side chains. Resulting peptides having terminal hydrophobic amino acids can result in a product with a bitter aftertaste. For this reason, papain is usually combined with other enzymes in the production of flavorings. Because papain is a thiol protease, oxidation of its cysteine residue under certain conditions can reduce the enzyme's activity or potency. For this reason papain preparations often contain reducing agents such as sodium metabisulfite. Papain is economically available commercially in both liquid and powder forms. It has the longest history of use in meat systems and is the basis for some of the popular tenderizing sprinkle-on products that can be purchased by home consumers (Enzyme Development Corporation, 1999). |
| Brand name | Caroid (Sterling Winthrop). |
| Therapeutic Function | Enzyme, Wound adhesion inhibitor |
| General Description | Papain (Papase), the dried and purifiedlatex of the fruit of Carica papaya L. (Caricaceae), can digestprotein in either acidic or alkaline media; it is best at a pH between4 and 7 and at 65°C to 90°C. It occurs as light brownishgray to weakly reddish brown granules, or as a yellowishgray to weakly yellow powder. It has a characteristic odor andtaste and is incompletely soluble in water to form an opalescentsolution. The commercial material is prepared by evaporatingthe juice, but the pure enzyme has also been preparedand crystallized. In medicine, it has been used locally in variousconditions similar to those for which pepsin is used. Ithas the advantage of activity over a wider range of conditions,but it is often much less reliable. Intraperitoneal instillation ofa weak solution has been recommended to counteract a tendencyto develop adhesions after abdominal surgery, and severalenthusiastic reports have been made about its value underthese conditions. Papain has been reported to cause allergiesin persons who handle it, especially those who are exposed toinhalation of the powder. |
| Biological Activity | papain is a cysteine protease of the peptidase c1 family, which is used in food, pharmaceutical, textile, and cosmetic industries. |
| Biochem/physiol Actions | Papain is a cysteine protease that cleaves peptide bonds and is known to cleave the Fc portion of antibodies. |
| Safety Profile | Poison by intraperitoneal route. Human systemic effects by ingestion: changes in structure or function of esophagus. Experimental teratogenic and reproductive effects. An allergen. When heated to decomposition it emits toxic fumes of NOx. |
| Purification Methods | A suspension of 50g of papain (freshly ground in a mortar) in 200mL of cold water is stirred at 4o for 4hours, then filtered through a Whatman No 1 filter paper. The clear yellow filtrate is cooled in an ice-bath while a rapid stream of H2S is passed through it for 3hours, and the suspension is centrifuged at 2000rpm for 20minutes. Sufficient cold MeOH is added slowly with stirring to the supernatant to give a final MeOH concentration of 70 vol%. The precipitate, collected by centrifugation for 20minutes at 2000rpm, is then dissolved in 200mL of cold water, the solution is saturated with H2S, centrifuged, and the enzyme is again precipitated with MeOH. The process is repeated four times. [Bennett & Niemann J Am Chem Soc 72 1798 1950.] Papain has also been purified by affinity chromatography on a column of GlyGlyTyrArg-agarose [Stewart et al. J Am Chem Soc 109 3480 1986]. |
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