CAS 9002-04-4 Thrombin Powder

Product Details
Customization: Available
CAS No.: 9002-04-4
Formula: /
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  • CAS 9002-04-4 Thrombin Powder
  • CAS 9002-04-4 Thrombin Powder
  • CAS 9002-04-4 Thrombin Powder
  • CAS 9002-04-4 Thrombin Powder
  • CAS 9002-04-4 Thrombin Powder
  • CAS 9002-04-4 Thrombin Powder
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  • Overview
  • Company Informations
  • Product Description
  • FAQ
  • Our Advantages
  • Product analysis
  • Detailed Photos
Overview

Basic Info.

Model NO.
YB178
EINECS
232-648-7
Environmental Protection
No
Certification
ISO9001
Color
White
Classification
Coenzyme
Function
Catalysis
Appearance
Powder
Type
Pharmaceutical Intermediates
Quality
Refined
Colour
White
Samples
Available
Certificates
ISO9001/SGS
Package
1kg/5kg/10kg/25kg
Stocks
in Stock
Lead Time
5-7 Working Days
Shelf Life
2-3 Years
Site Audit
Available
Transport
Air/Express/Sea
MOQ
1 Unit
Payment Method
LC/Tt/DAP/OA
Form
Powder
Purity
99%
Transport Package
Drum/Bottle/Bags
Specification
40-300u/mg
Trademark
Yunbang OEM
Origin
China

Product Description

CAS 9002-04-4 Thrombin powder
 
Company Informations

Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.

The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products.
We can perform -100°C to 300°C reaction.

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.


Our goal : To achieve the integrated upgrade of Pharmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating our brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.

 
Product Description

Thrombin is a serine protease enzyme that plays a crucial role in the clotting process of blood, known as hemostasis. It is produced from its precursor, prothrombin, through the cleavage of specific peptide bonds by activated coagulation factors. Thrombin acts at the convergence of the intrinsic and extrinsic coagulation pathways and serves several essential functions in the coagulation cascade.

One of its primary roles is to convert soluble fibrinogen into insoluble strands of fibrin, which polymerize to form a stable blood clot. This conversion is a key step in the process of coagulation and is vital for the prevention of excessive bleeding following injury.

Thrombin also exhibits regulatory functions by activating other coagulation factors and platelets, amplifying the coagulation response and promoting the formation of a stable clot. Additionally, it participates in a feedback loop by activating factors such as factor V, factor VIII, and factor XI, further enhancing the coagulation process.

Outside of its role in coagulation, thrombin has been implicated in other physiological processes, including inflammatory responses, cell signaling, and tissue repair. It exerts these effects through the activation of protease-activated receptors (PARs) present on the surface of various cell types.

In summary, thrombin is a multifunctional serine protease that acts as a central player in the coagulation cascade, facilitating the formation of blood clots and contributing to the overall maintenance of hemostasis. Its diverse roles make it a critical enzyme in both normal physiological functions and pathological conditions related to coagulation and inflammation.

Application

Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess persistent hypocoagulability in patients with septic shock. 
 
FAQ

1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.

2: What's your MOQ?
A: We can have a discussion.

3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.

4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.

5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.

6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Our Advantages

1. 90days quality guarantee for exchange.

2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.

3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.

 

Product analysis
Product Name: Thrombin
Synonyms: Blood coagulation factor IIa;Thrombin from human plasma,Factor IIa;Thrombin from murine plasma,Factor IIa;Thrombin from bovine plasma,Factor IIa;THROMBIN, BOVINE;ThroMbin froM bovine plasMa 1000 units/Mg protein lyophil.;COAGULATION FACTOR IIA;EC 3.4.21.5
CAS: 9002-04-4
MF: NULL
MW: 0
EINECS: 232-648-7
Product Categories: proteins
Mol File: Mol File
 
Melting point  47.7 °C
storage temp.  -20°C
solubility  H2O: 1 mL/vial clear to slightly hazy, colorless solution
form  powder
color  white
Merck  13,9461
EPA Substance Registry System Thrombin (9002-04-4)
Hazard Codes  Xn,B,Xi
Risk Statements  36/37/38-42
Safety Statements  22-24/25-36/37-26-24
WGK Germany  2
RTECS  XO8950000
TSCA  Yes
HS Code  30021099
 
Description In order to stop local bleeding, thrombin, a natural thrombin drug that catalyzes the transformation of fibrinogen to fibrin, is frequently used. Thrombin is synthesized from cow plasma, and it is used to stop bleeding from open vessels when it is not possible to use other methods. It is used to stop light bleeding.
Uses Thrombostat (Parke-Davis).
Uses Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a haemostatic plug or a pathologic thrombus
Uses Thrombin is used in coagulation research, medical research, protein-structure analysis, and biochemical research. It has been used for the stimulation of the platelets.
General Description Thrombin is a sterile protein substanceprepared from prothrombin of bovine origin. It is used as atopical hemostatic because it can clot blood, plasma, or a solutionof fibrinogen without addition of other substances.Thrombin also may initiate clotting when combined withgelatin sponge or fibrin foam.
For external use it is applied topically to the wound, as asolution containing 100 to 2,000 National Institutes ofHealth (NIH) units/mL in sodium chloride irrigation or sterilewater for injection or as a dry powder.
Biochem/physiol Actions The main function of thrombin is the cleavage of fibrinogen to fibrin, to assist stable clot formation. A wide range of mutations in the prothrombin gene contributes to its deficiency resulting in coagulation disorders like dysprothrombinemia and hypoprothrombinemia. High levels of thrombin elicit neurotoxicity in dopaminergic neurons and contributes to the progression of Parkinson′s disease. Altered thrombin levels modulates the coagulation pathway in multiple sclerosis. Patients with coronary artery disease (CAD) show elevated levels of thrombin. Thrombin accumulation in neurofibrillary tangles of the brain may contribute to the aggregation of tau protein and pathophysiology of Alzheimer disease.
Purification Methods Thrombin is purified by chromatography on a DEAE-cellulose column, while eluting with 0.1M NaCl, pH 7.0, followed by chromatography on Sephadex G-200. The final preparation is free from plasminogen and plasmin. [Yin & Wessler J Biol Chem 243 112 1968.] Thrombin from bovine blood is also purified by chromatography using p-chlorobenzylamino--aminocaproyl agarose, and gel filtration through Sephadex G-25. [Thompson & Davie Biochim Biophys Acta 250 210 1971.] Thrombin from various species was purified initially by precipitation of impurities with rivanol. [Miller Nature 184 450 1959.] Tissue inhibitor of metalloproteins (TIMP, from human blood plasma), Mr ~30,000. These are purified by an [anti-human amniotic fluid-TIMP]-Sepharose immuno-affinity column and eluted with 50mM glycine/HCl pH 3.0 buffer that is 0.5M in NaCl, and followed by gel filtration [Cawston et al. Biochem J 238 677 1986].
Detailed Photos

 

CAS 9002-04-4 Thrombin Powder
CAS 9002-04-4 Thrombin Powder
CAS 9002-04-4 Thrombin Powder
CAS 9002-04-4 Thrombin Powder
CAS 9002-04-4 Thrombin Powder
CAS 9002-04-4 Thrombin Powder
CAS 9002-04-4 Thrombin Powder
CAS 9002-04-4 Thrombin Powder



 

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