| Customization: | Available |
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| CAS No.: | 9001-08-5 |
| Formula: | / |
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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".Butyrylcholinesterase, also known as pseudocholinesterase, is an enzyme that belongs to the family of cholinesterases. It is primarily found in the blood plasma and certain tissues in the body. Butyrylcholinesterase plays a crucial role in the hydrolysis of choline esters, including the neurotransmitter acetylcholine and other choline-based esters.
The main function of butyrylcholinesterase is to hydrolyze and inactivate choline esters, thereby regulating their activity. For example, it can hydrolyze acetylcholine at neuromuscular junctions, terminating the action of the neurotransmitter and allowing for proper muscle relaxation. Additionally, butyrylcholinesterase has the ability to hydrolyze other choline esters, such as succinylcholine, which is used as a muscle relaxant during anesthesia.
Butyrylcholinesterase is also implicated in the metabolism of various xenobiotic compounds, including certain drugs and toxins that contain ester groups. Its enzymatic activity contributes to the detoxification and clearance of these compounds from the body.
In the field of pharmacology, butyrylcholinesterase is of interest due to its role in the metabolism of certain drugs, as well as its potential as a biomarker for various conditions. Changes in butyrylcholinesterase activity or levels in the blood can be associated with liver disease, genetic variations, and exposure to certain chemicals.
In summary, butyrylcholinesterase is an important enzyme involved in the hydrolysis of choline esters, including acetylcholine, and the metabolism of xenobiotic compounds. Its activity contributes to the regulation of neurotransmission, the detoxification of ester-containing compounds, and its potential role as a biomarker for various physiological and pathological conditions.
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | Butyrylcholinesterase |
| Synonyms: | ACYLCHOLINE ACYL-HYDROLASE;BUTYRYL CHOLINESTERASE;BUTYRYLCHOLINE ESTERASE;IUB: 3.1.1.8;BUTYRYLCHOLINE ESTERASE FROM HORSE SERUM, ~250 U/MG*;CHOLINESTERASE BUTYRYL FROM HUMAN SERUM;BUTYRYLCHOLINESTERASE, HUMAN;BUTYRYLCHOLINE ESTERASE F. HORSE SERUM, LYOPH., ~10 U/MG |
| CAS: | 9001-08-5 |
| MF: | |
| MW: | 0 |
| EINECS: | 232-579-2 |
| Product Categories: | 3.1.x.x Acting on esters;3.x.x.x Hydrolases;Enzyme Class Index |
| Mol File: | Mol File |
| storage temp. | -20°C |
| form | powder |
| color | light brown |
| Merck | 13,2229 |
| EPA Substance Registry System | Esterase, choline (9001-08-5) |
| Hazard Codes | B |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 10-21 |
| Uses | Butyrylcholinesterase from equine serum has been used in a microcalorimetric study of the inhibition of butyrylcholinesterase by paraoxon. This enzyme has also been used in a study to investigate the synthesis and inhibition of cholinergic enzymes. Selective inhibition of BChE activity can be used in the detection of organophosphates. Its use in the treatment of organophosphate toxicity has shown clinical potential, as there is a correlation between the blood level of BChE in humans and the degree of protection against toxic nerve agents. There has also been an interest in the roles of cholinesterases with regard to Alzheimer′s disease. Investigations into selective inhibitors may provide a clearer picture of the physiological role of BChE in both healthy and diseased individuals. This product has been used for the screening of cholineesterase inhibitors in selected fruits and vegetables, for restoring cognitive function and improving memory. It has also been used to develop a butyrylcholinesterase and choline oxidase immobilized bio-sniffer for the detection of nicotine. Nicotine inhibits BChE activity. A decrease in the byproducts of BChE activity reflects the volume of nicotine. |
| Uses | Selective inhibition of BChE activity, Butyrylcholinesterase can be used in the detection of organophosphates.Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents.Cholinesterases have also been investigated for their role in Alzheimer's disease. |
| Biological Functions | Butyrylcholinesterase (BuChE) is found in plasma, the liver, and the kidney. Its activity is also inhibited by carbamate insecticides. BuChE is able to hydrolyze much larger substrates than AChE due to differences in their structure that allow BuChE to bind bulky ligands. The physiological role of BuChE is not completely understood, but it represents an important detoxification pathway for anticholinesterase compounds (Sultatos, 2006). |
| General Description | Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). It is also termed as pseudocholinesterase. It is produced in the liver. It is found in blood, the synapse of neuromuscular junctions and glia cells and axons of white matter. |
| Biochem/physiol Actions | Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities.BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+. The activity is constant over the pH range of 6.0-8.0. It is inhibited by betaine, nicotine, organophosphates, and carbamate. |
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