| Type: | Pharmaceutical Intermediates |
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| Appearance: | Powder |
| Quality: | Refined |
| CAS No.: | 77-09-8 |
| Formula: | C20h14o4 |
| Einecs: | 201-004-7 |
| Samples: |
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| Customization: |
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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | Phenolphthalein |
| Synonyms: | 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-;1(3H)-Isobenzofuranone,3,3-bis(4-hydroxyphenyl)-;2,2-bis(p-hydroxyphenyl)phthalide;3,3-bis(4-hydroxyphenyl)-1(3h)-isobenzofuranon;alpha-(p-hydroxyphenyl)-alpha-(4-oxo-2,5-cyclohexadien-1-ylidine)-o-toluicacid;alpha-di-(p-hydroxyphenyl)phthalide;Chocolax;component of Correctol |
| CAS: | 77-09-8 |
| MF: | C20H14O4 |
| MW: | 318.32 |
| EINECS: | 201-004-7 |
| Mol File: | 77-09-8.mol |
| Melting point | 261-263 °C (lit.) |
| Boiling point | 417.49°C (rough estimate) |
| density | 1.27 g/cm3 at 32 °C |
| refractive index | 1.5400 (estimate) |
| Fp | 24 °C |
| storage temp. | no restrictions. |
| solubility | Soluble in alcohol. Slightly soluble in ether. |
| form | Solid |
| pka | 9.4(at 25ºC) |
| Colour Index | 764 |
| color | White to yellow-white |
| PH Range | 8.0(colorless)-10(Red) |
| PH | 7.8~10.0 |
| Odor | Odorless |
| Water Solubility | <0.1 g/100 mL |
| λmax | 552nm, 553nm, 374nm, 205nm, 229nm, 276nm |
| Merck | 14,7243 |
| BRN | 284423 |
| Stability: | Stable. Incompatible with strong oxidizing agents, alkalies. |
| Major Application | Display device, sensors, semiconductors, fuel cells, photoreceptors, electronic packaging, authentication system for secure documents, inks, correction fluid, paints, detection of defects in films, floor coatings, textiles, corrosion testing, explosive, concrete, toys, detecting lipase activity of crop seeds, soaps, method for prevention of drugmisuse, cosmetics, diapers, detecting viable cells, carbohydrates, antimalarial, treating amyloid-associated diseases |
| LogP | 2.410 |
| CAS DataBase Reference | 77-09-8(CAS DataBase Reference) |
| IARC | 2B (Vol. 76) 2000 |
| NIST Chemistry Reference | Phenolphthalein(77-09-8) |
| EPA Substance Registry System | 3,3-Bis(4-hydroxyphenyl)phthalide (77-09-8) |
| Hazard Codes | Xn,T,F,Xi |
| Risk Statements | 40-22-10-36/38-23/25-11-36/37/38-68-62-45-39/23/24/25-23/24/25 |
| Safety Statements | 45-36/37-33-24-16-7-36-26-53 |
| WGK Germany | 3 |
| RTECS | SM8380000 |
| TSCA | Yes |
| HS Code | 29322910 |
| Hazardous Substances Data | 77-09-8(Hazardous Substances Data) |
| acid-base indicator | Phenolphthalein is another weak organic acid. It is not particularly water soluble, so we generally dissolve it in aqueous ethanol. The ethanol explains the pleasant, sweet smell of phenolphthalein solutions. Phenolphthalein is colourless and clear in acidic solutions, but imparts an intense puce pink colour in alkaline solutions of higher pH, with λ(max) = 552 nm. The coloured form of phenolphthalein contains a quinone moiety; in fact, any chromophore based on a quinone has a red colour. But if a solution is prepared at pH 7 (e.g. as determined with a pH meter), we find the phenolphthalein indicator is still colourless, and the pink colour only appears when the pH reaches 8.2. Therefore, we have a problem: the indicator has not detected neutrality, since it changes colour at too high a value of pH. in fact, only a tiny incremental addition of alkali solution is needed to substantially increase the solution pH by several pH units. In other words, a fraction of a drop of alkali solution is the only difference between pH 7 (at the true volume at neutralization) and pH 8 when the phenolphthalein changes from colourless to puce pink. Figure 1 lists the pH changes for a series of common pH indicators. The colour changes occur over a wide range of pHs, the exact value depending on the indicator chosen. Methyl violet changes from yellow to blue as the pH increases between 0 and 1.6. At the opposite extreme, phenolphthalein responds to pH changes in the range 8.2 to 10. |
| General Description | Phenolphthalein mainly acts on the large intestine, which produces semi-liquid excreta in 4 to 8 hours with little or no colic. The claim that yellow phenolphthalein is three times stronger than white remains unproven. As a result of enterohepatic circulation, the effect of a single dose is sustainable for 3 to 4 days. The drug is an active member of many laxatives that can be sold legally without prescription. Serious adverse effects are rare but can occur when used in excess. Phenolphthalein should be avoided on the elderly, because its long-term role can cause severe depletion of water and electrolytes. Dermatitis (fixed rash, itching, burning sensation, blistering, and residual pigmentation) can occur in allergic patients. There were reports of a fatal anaphylaxis but no definite causative relationship with phenolphthalein. There are occasional reports of non-thrombocytopenic purpura. Long-lasting administration can occasionally caused dehydration and electrolyte imbalance due to excessive diarrhea. Phenolphthalein causes alkaline urine or faeces pink. |
| Pharmacology and Toxicology | Phenolphthalein can be used for the treatment of habitual refractory constipation, mainly acting on the colon. After oral administration, it can be subject to slowly decomposition under the effect of the small intestinal alkaline fluid to form soluble sodium salt, thereby stimulating the plexus inside the intestinal wall. It directly acts on the intestinal smooth muscle and increase peristalsis, while also inhibiting the absorption of water within the intestine, so that water and electrolyte accumulates in the colon, resulting in laxative effect. It has mild effect and rarely causes intestinal cramps. |
| Pharmacokinetics | About 15% is absorbed after oral administration. The absorbed drugs mainly exist in the form of glucuronide to be excreted from urine or the feces, some can also be excreted to the intestine through the bile, reabsorbed in the intestine, to form intestinal - liver circulation and prolong the role time. At 4 to 8 hours after the drug administration, the patients will discharge soft stool. The excretion time for drug administration once needs 3 to 4 days. This product can also be secreted from milk. |
| Application | This product is a commonly used acid indicator with the range of color change between pH 8.2 (colorless) to 10.0 (red). Phenolphthalein is also a drug, can be used as a laxative, acting on the colon for the treatment of constipation. Used as an acid-base indicator; as irritant laxative for the treatment of constipation |
| Chemical Properties | white to light yellow crystal powde |
| Uses | Phenolphthalein is one of those chemicals that is commonly used in the chemistry laboratory to tell if a solution is acidic or alkaline . These chemicals are called acid - base indicators and used as indicator for acidimetric titrations. Phenolphthalein exerts laxative effects by stimulating the intestinal mucosa and constricting smooth muscles. However, phenolphthalein is no longer used as a laxative due to the suspected carcinogenicity of this compound. |
| Uses | Phenolphthalein can be used as an inhibitor and pH indicator. It also induces centrosome amplification and tubulin depolymerization in vitro. |
| Definition | phenolphthalein: A dye used as anacid-base indicator. It is colourlessbelow pH 8 and red above pH 9.6. Itis used in titrations involving weakacids and strong bases. It is also usedas a laxative. |
| Brand name | Evac-Q-Tabs (Savage); Ex-Lax (Novartis); Modane (Savage); Prulet (Mission Pharmacal);Agaffin;Alophen pills;Anodyne dellipsoids 4;Ap-la-day;Bold laxine;Bom-bon;Bon-bon;Canisan;Certolax;D & m tablets;Darmol;Euchessinia;Evac-qwik tablets;Evactil;Feen-a-mint;Fractines vichy;Fractine-vichy;Fructines-vichy;Kalimalterin;Kest;Kondremul with phenolphtalein;Laxante yer;Laxatabs;Laxatone;Laxen busto;Minilax;Modane plus;Mucinum;Musilaks;Neoprunex;Neopurghes;Novopuren;Paradeines;Peplax;Petrolaglar emulsion;Petro-mul-phen;Phillips laxcaps;Prifunal;Prunetta;Pugrante el aleman;Purganol;Purganos-daguin;Purgant aleman;Purgante orravan;Purgenum;Purgestol;Purgoids;Purgyl;Purjen sahap;Sarolax;Thalinol mrt;Unisvelt;Veracolate. |
| World Health Organization (WHO) | Phenolphthalein has been widely used as a laxative since its cathartic activity was first described in 1902. Because it undergoes enterohepatic circulation it is eliminated slowly and it has been associated with adverse effects, notably skin reactions, potassium loss and atonia. This has led to the withdrawal of phenolphthalein from pharmaceutical preparations in several countries. Elsewhere, it remains available, often in over-the-counter preparations. |
| General Description | Phenolphthalein solution is a synthetic indicator. It is colorless in acidic and neutral conditions. Phenolphthalein gives pink color when added to a base, therefore it is considered as a base indicator. |
| Safety Profile | Confirmed carcinogen. US Food and Drug Administration recommends removal from laxative formulations. Moderately toxic by intraperitoneal route. Human systemic effects: changes in urine composition, gastritis, nausea or vomiting. Used in medicine as a laxative; in chemistry as an indicator. When heated to decomposition it emits acrid smoke and irritating fumes |
| Carcinogenicity | Phenolphthalein is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. |
| Purification Methods | Dissolve it in EtOH (7mL/g), then dilute it with eight volumes of cold water, filter and heat on a water-bath to remove most of the alcohol and the phenolphthalein that precipitates is filtered off and dried in vacuo.[Beilstein 18 II 119, 18 III/1V 1945, 18/4 V 188.] |
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