| CAS No.: | 103476-89-7 |
|---|---|
| Formula: | C20h40n6o8s |
| EINECS: | 600-443-5 |
| Environmental Protection: | No |
| Certification: | ISO9001 |
| Color: | White to off-White |
| Samples: |
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| Customization: |
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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".Leupeptin is a naturally occurring protease inhibitor that belongs to the class of acylated oligopeptides.
In laboratory settings, leupeptin is commonly used to prevent the degradation of proteins in cell and tissue extracts, as well as in purification protocols where protease activity needs to be controlled.
Furthermore, leupeptin has been investigated for its potential therapeutic applications, particularly in the context of neurodegenerative diseases and cancer. I
In summary, leupeptin is a protease inhibitor with broad-spectrum activity, offering applications in the study of protein degradation, cellular processes, and potential therapeutic interventions. Its role in preserving protein integrity and its potential in mitigating protease-related pathology underscore its significance in biochemical and biomedical research.
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | Leupeptin |
| Synonyms: | AC-LEU-LEU-ARGININAL HEMISULPHATE;AC-LEU-LEU-ARGININAL X 1/2 H2SO4;AC-LEU-LEU-L-ARGININAL;AC-LLR-CHO;AC-LLR-CHO, 1/2H2 SO4;N-ACETYL-L-LEUCYL-L-LEUCYL-L-ARGININAL HEMISULFATE;Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate;leupeptin hemisulfate from microbial*source |
| CAS: | 103476-89-7 |
| MF: | C20H40N6O8S |
| MW: | 524.63 |
| EINECS: | 600-443-5 |
| Product Categories: | Inhibitors;peptides;inhibitor;ProteaseInhibitors;Pepetides;Protease |
| Mol File: | 103476-89-7.mol |
| alpha | -76 º (c=1, water) |
| storage temp. | -20°C |
| solubility | H2O: 10 mM Solutions are stable for a week at 4 °C. Stock solutions are stable up to 6 months at −20°C. |
| form | Powder |
| color | White to Off-white |
| Water Solubility | soluble |
| InChIKey | CIPMKIHUGVGQTG-VFFZMTJFSA-N |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-63-36/37/38 |
| Safety Statements | 22-24/25-36/37-36-36/37/39-26-7/8 |
| RIDADR | 3077 |
| WGK Germany | 3 |
| F | 10-23 |
| HS Code | 29252900 |
| Chemical Properties | White to off-white lyophilized powder |
| Uses | Leupeptin has been used as a protease inhibitor: in ice-cold lysis buffer to harvest cells for western immunoblotting and immunoprecipitation,in chromatin immunoprecipitation (ChIP) lysis buffer for the isolation of fragmented chromatin samples in lysis buffer I to lyse the cells for tandem affinity purification (TAP) |
| Uses | Leupeptin as well as other protease inhibitors like antipain, chymostatin, pepstatin, and phosphoramidon are useful for the protection of proteins during their isolation from tissues or membranes. Leupeptin can be removed from the reaction by dialysis. Note: To check other protease inhibitors, try our Protease Inhibitor Set including Antipain Dihydrochloride, Aprotinin, Bestatin, Chymostatin, E-64, EDTA-Na2, Leupeptin, Pefabloc SC, Pepstatin, and Phosphoramidon. |
| Definition | ChEBI: A peptide sulfate salt obtained by combining leupeptin with 0.5 molar equivalents of sulfuric acid. |
| storage | +4°C |
| References | 1) Aoyagi?et al.?(1969),?Leupeptins, new protease inhibitors from Actinomycetes; J. Antibiot.,?22?283 2) Barrett?et al.?(1981),?Cathepsin B, Cathepsin H and Cathepsin L; Methods Enzymol., Pt C,?80?535 3) Knight?et al. (1980),?Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin; Biochem. J.,?189?447 4) Sarin?et al. (1995),?A protease-dependent TCR-induced death pathway in mature lymphocytes; J. Immunol.,?154?5806 |
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