Arotinolol Hydrochloride CAS 68377-91-3 Arotinolol HCl

• CAS No.: 68377-91-3
• Formula: C15h22cln3o2s3
• Appearance: Powder
• Type: Pharmaceutical Intermediates
• Quality: Refined
• Colour: White
• Samples: Available
• Purity: 99%
• Certificates: ISO9001/SGS
• Package: 1kg/5kg/10kg/25kg
• Stocks: in Stock
• Lead Time: 5-7 Working Days
• Shelf Life: 2 Years
• MOQ: 10g
• Transport: Air/Express/Sea
• Site Audit: Available
• Transport Package: Drum/Bottle/Bags
• Trademark: Yunbang
• Origin: China

Product Description

Arotinolol hydrochloride CAS  68377-91-3 arotinolol hcl

AROTINOLOL HCL Chemical Properties

Melting point	234-235.5° (dec)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Merck	14,791

Safety Information

RIDADR	UN 2811 6.1/PG III
RTECS	XM8301000
HazardClass	6.1
PackingGroup	III
Toxicity	LD50 in mice (mg/kg): 86 i.v., >360 i.p., >5000 orally (Hara)

MSDS Information

 

AROTINOLOL HCL Usage And Synthesis

Description	Arotinolol hydrochloride i s a β-adrenergic blocker with weak α-antagonistic properties, useful in the treatment of hypertension.
Originator	Sumitomo (Japan)
Manufacturing Process	To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in 20 ml of 0.3 % aqueous sod ium hydro xide solution, 1-chloro-3-tbutylaminopropanol, 12.64 g in 20 ml of meth anol was added, while the temperature was maintained at 20°C. The reaction solution was stirred at room temperature for 4 h, and then condensed to a half volume in vacuo. The residual solution, added with 100 ml of water, was extracted with chlor oform. The chlo roform extract was washed with water, dried over anhydrous magnesium sulfate and evaporated in vacuo to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'- thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec., recrystallized from meth anol/water). In practice it is usually used as hydrochloride.
Brand name	ALMARL
Therapeutic Function	Beta-adrenergic blocker

AROTINOLOL HCL Preparation Products And Raw materials

 

Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products.
We can perform -100°C to 300°C reaction.

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.

Our goal : To achieve the integrated upgrade of Pharmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating our brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.