CAS 373-68-2 Tetramethylammonium Fluoride
Company Profile
Hunan Yunbang Biotech Inc. was established in 2008. Its predecessor originated from Beijing Yunbang Biosciences Co., Ltd. and moved to Changsha, Hunan in 2016. Is a professional engaged in research and development, production and sales in one of the raw materials for IVD reagents, Biological buffers, Zwitterionic detergents,Pharmaceutical raw materials and Fine Chemicals.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".
We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products.
We can perform -100°C to 300°C reaction.
R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.
Our goal : To achieve the integrated upgrade of Pharmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating our brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.
FAQ
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Product analysis
| Product Name: |
Tetramethylammonium fluoride |
| Synonyms: |
Tetramethylammonium Fluoridede;n,n,n-trimethyl-methanaminiufluoride;TETRAMETHYLAMMONIUM FLUORIDE;Tetramethylammoniumfluoride,20%AqueousSolution;Tetramethylammonium fluoride, anhydrous;Methanaminium, N,N,N-trimethyl-, fluoride;Tetramethylazanium fluoride;Tetramethylaminium·fluoride |
| CAS: |
373-68-2 |
| MF: |
C4H12FN |
| MW: |
93.14 |
| EINECS: |
206-769-0 |
| Product Categories: |
Deprotecting Reagents;Fluoride Sources;quarternary ammonium salts;Protection and Derivatization |
| Mol File: |
373-68-2.mol |
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| Tetramethylammonium fluoride Chemical Properties |
| Melting point |
170 °C (dec.) (lit.) |
| InChIKey |
HQFTZNVQVRRDLN-UHFFFAOYSA-M |
| CAS DataBase Reference |
373-68-2(CAS DataBase Reference) |
| EPA Substance Registry System |
Tetramethylammonium fluoride (373-68-2) |
| Hazard Codes |
Xn |
| Risk Statements |
20/21/22-36/37/38 |
| Safety Statements |
26-36 |
| RIDADR |
2811 |
| WGK Germany |
3 |
| HazardClass |
6.1(b) |
| PackingGroup |
III |
| HS Code |
29239000 |
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| Tetramethylammonium fluoride Usage And Synthesis |
| Description |
Tetramethylammonium fluoride is the quaternary ammonium salt with the formula (CH3)4NF. This hygroscopic white solid is a source of "naked fluoride", that is fluoride ions not connected to a metal atom in a complex. Most other soluble salts of fluoride are in fact bifluorides, HF2-. Historically, there has been two main approaches to prepare TMAF:
(ii) through the metathesis reaction of different ammonium salts with inorganic sources of fluoride such as KF or CsF.
Due to the high basicity of the fluoride anion, the salt reacts slowly with acet-onitrile, inducing its dimerization to CH3C(NH2)=CHCN, which co-crystallizes. |
| Uses |
Tetramethylammonium fluoride may be used in combination with for the conversion of aryl phenols to aryl fluorides. It can react with aminosilanes to generate onium amide bases in situ, which can deprotonate heteroarenes. |
| Uses |
Reactant for:
- Halide-induced ring opening of 2-substituted aziridinium salts
- Synthesis of fluoro aromatics via fluorodenitration reactions
- Synthesis of sevoflurane in ionic liquids by halogen-exchange fluorination
- Synthesis of fluorinated Poly(oxomolybdates)
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