| Customization: | Available |
|---|---|
| CAS No.: | 9001-12-1 |
| Formula: | C60h100n2 |
|
Still deciding? Get samples of $ !
Request Sample
|
Suppliers with verified business licenses
Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".Collagenase derived from Clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum, and it belongs to the class of proteolytic enzymes that specifically target collagen, the main structural protein in the extracellular matrix of connective tissues. This enzyme exhibits the ability to selectively hydrolyze peptide bonds in collagen, leading to the breakdown of collagen fibers into smaller peptides and amino acids.
The unique capability of collagenase to degrade collagen has led to its wide application in various fields. In medicine, it is utilized in procedures such as enzymatic debridement of necrotic tissues, wound healing, and the treatment of conditions such as Dupuytren's contracture and Peyronie's disease. Additionally, collagenase from Clostridium histolyticum is used in the isolation of cells from tissues, as it aids in the dissociation of connective tissues and the release of individual cells for culture.
In biotechnology and research, collagenase plays a crucial role in the isolation and manipulation of cells from animal and plant tissues, as well as in the study of extracellular matrix and tissue remodeling. Furthermore, it is employed in the food and cosmetic industries for its ability to tenderize meats and enhance the texture of certain products.
Overall, the unique proteolytic activity of collagenase from Clostridium histolyticum makes it a valuable tool in various applications, ranging from biomedical and clinical uses to biotechnology and beyond.
Application
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | Collagenase |
| Synonyms: | COLLAGENASE TYPE X;Collagenase from Clostridium histolyticum;collagenase crude type ia cell culture*tested;collagenase F. clostridium histolyticum;collagenase from achromobacter iophagus;collagenase sterile filtered type vii-S;collagenase type I-S;Collagenase A |
| CAS: | 9001-12-1 |
| MF: | C60H100N2 |
| MW: | 849.4494 |
| EINECS: | 232-582-9 |
| Product Categories: | STREPTOKINASE;Biochemistry;Enzyme;Hydrolase;9001-12-1 |
| Mol File: | 9001-12-1.mol |
| storage temp. | -20°C |
| solubility | Soluble in aqueous buffers. |
| form | powder |
| color | light brown |
| PH | 7.0 |
| Merck | 2481 |
| CAS DataBase Reference | 9001-12-1 |
| EPA Substance Registry System | Collagenase (9001-12-1) |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42 |
| Safety Statements | 22-24-26-36/37 |
| WGK Germany | 1 |
| F | 10-21 |
| HS Code | 3507907000 |
| Description | Collagenases are a category of enzymes that can digest native collagen, the major fibrous component of animal extracellular connective tissue. Collagenases can be produced by some bacterias such as Clostridium and can also be made by the animal body as part of its normal immune response. They normally target the connective tissue in muscle cells and other body organs. They can break peptide bonds within collagen and help create collagen by cleaving pro-collagen, collagen's precursor, once it is secreted by the cell. Bacterial collagenases exhibit broader substrate specificity than animal collagenases and unlike animal collagenases that split collagen in its native triple-helical conformation, bacterial collagenase can degrade both water-insoluble native collagens and water-soluble denatured ones. In addition, bacterial collagenase can attack almost all collagen types, and is able to make multiple cleavages within triple helical regions. Collagenases have a molecular weight ranging from 68 kilodaltons (kDa) to 130 Kda due to differing sizes based on the class to which the isolate belongs. The optimal pH for stability ranges from approximately 6.3 to 7.5 with a theoretical isoelectric point of 5.62. Numerous compounds and molecules have the capability of acting as collagenases activator or inhibitor. For example, Ca2+ and Zn2+ ions are two known activators. On the other hand, ethylenediaminetetraacetic acid (EDTA), ethylene glycol tetraacetic acid (EGTA), cysteine, histidine, dithiothreitol (DTT), 2-mercaptoethanol, o-phenanthroline, Hg2+, Pb2+, Cd2+, Cu2+, and Zn2+ are all known inhibitors of collagenase activity. |
| Uses | This collagenase has been tested with cell lines to verify the product is not cytotoxic. Collagenase is typically used to digest the connective components in tissue samples to liberate individual cells. The concentration for cartilage dispersal is 1-2 mg/ml, but literature searches should be performed for species specific and/or tissue specific concentrations. |
| Uses | In investigation of the structure and biosynthesis of collagen; in dispersion of cells for tissue culture studies. |
| Uses | Collagenase, Type I, Clostridium histolyticum is used as a powder and solvent injection kit for the treatment of dupuytren's contracture. |
| Definition | A rare proteinase that catalyzes the hydrolysis of collagen. Collagenase activity has been demonstrated in several venoms of crotalid and viperid snakes and it occurs in certain species of clostridium. |
| Purification Methods | Collagenase is purified by using N-ethylmaleimide to activate the enzyme, and wheat germ agglutinin-agarose affinity chromatography [Callaway et al. Biochemistry 25 4757 1986]. |
){kind=link}