| Customization: | Available |
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| CAS No.: | 556743-18-1 |
| Formula: | / |
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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".Lumbrokinase is a group of proteolytic enzymes derived from the earthworm Lumbricus rubellus. These enzymes exhibit fibrinolytic activity, meaning they are capable of breaking down fibrin, a protein involved in blood clot formation. Lumbrokinase has been studied for its potential therapeutic effects on cardiovascular health and its use in traditional Chinese medicine.
Research suggests that lumbrokinase may aid in promoting healthy blood circulation by reducing the risk of excessive clot formation and potentially preventing conditions such as deep vein thrombosis, arterial thrombosis, and stroke. Additionally, lumbrokinase has been explored for its potential in addressing conditions related to clot formation and cardiovascular health.
The fibrinolytic properties of lumbrokinase have led to its investigation as a natural alternative or complementary treatment in the management of cardiovascular and thrombotic disorders. However, it is important to note that further research and clinical studies are necessary to fully elucidate its efficacy and safety for therapeutic use.
In summary, lumbrokinase, derived from the earthworm Lumbricus rubellus, is a group of proteolytic enzymes with fibrinolytic activity. Its potential role in promoting cardiovascular health and preventing clot-related conditions has sparked interest in both traditional and modern medicine.
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | Lumbrokinase |
| Synonyms: | Lumbrokinase;lumbrokinase capsules;Vermis;LuMbokinase capsules;GenBank AAP92795 (Translated from: GenBank AY327442);Lumbrukinase;Lumbrokinase USP/EP/BP;Lumbrokinaseis |
| CAS: | 556743-18-1 |
| MF: | C12H15N3O2S |
| MW: | 0 |
| EINECS: | 211-390-9 |
| Product Categories: | |
| Mol File: | Mol File |
| Description | Lumbrokinase is a complex enzyme preparation extracted from earthworms. Lumbrokinase can also be referred to as earthworm powder enzymes (EPE) or earthworm fibrinolytic enzymes (e-PPA). Earthworms have been used in traditional Easter medicine for thousands of years in countries such as China, Japan and Korea. According to the ancient Chinese medical publication Ben Cao Gang Mu (Compendium of Chinese Botanical and Animal Products), earthworms or "Earth Dragons" possess the properties to "invigorate blood, resolve stasis, and unblock the body's meridians and channels." As a result, earthworms are commonly used in traditional herbal formulae that treat ischemic or thromboembolic conditions. Inspired by the empirical wisdom of traditional Eastern medicine, the Japanese started searching for ingredients that could account for the observed properties of earthworms. Finally, in 1983 Dr. Hisashi Mihara succeeded in extracting powerful fibrin-dissolving enzymes from earthworms and he named this group of enzymes lumbrokinase. Since then Korean and Chinese researchers have compiled extensive in-vitro, animal and clinical data on the properties and applications of lumbrokinase over the past 30 years. |
| Mechanisms of lumbrokinase | Lumbrokinase is a multiple enzyme preparation; naturally it also affects the coagulation system in multiple ways. Since the discovery of lumbrokinase by Dr. Mihara in 1983, various researchers have isolated the enzyme by different methods and also studied its physiological properties in animal models. All of the results pointed towards the fact that lumbrokinase possesses both direct and indirect fibrinolytic effects1-2. It can activate the plasminogen system and also can achieve direct fibrinolysis independent of the plasminogen system. In 2004, Zhang el al. discovered that lumbrokinase also inhibit PAI-1 activity and enhances t-PA activity3. In addition to being a strong fibrinolytic agent, lumbrokinase may indirectly achieve anticoagulation by inhibiting platelet functions. |
| Application | Lumbrokinase is a fibrinolytic enzyme present in the earthworm Lumbricus bimastus.It has been investigated as an experimental antithrombotic agent. |
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