| CAS No.: | 303-98-0 |
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| Formula: | C59h90o4 |
| EINECS: | 206-147-9 |
| Environmental Protection: | No |
| Certification: | ISO9001 |
| Color: | Light Orange to Dark Orange |
| Samples: |
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| Customization: |
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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".Coenzyme Q10, also known as CoQ10 or ubiquinone, is a naturally occurring compound found in the mitochondria of cells. It plays a vital role in the production of adenosine triphosphate (ATP), which is the primary energy source for cellular activities.
Coenzyme Q10 functions as an electron carrier in the electron transport chain, facilitating the conversion of energy from nutrients into ATP. This process occurs within the inner mitochondrial membrane and is essential for cellular respiration and energy production.
In addition to its role in energy metabolism, Coenzyme Q10 also exhibits antioxidant properties, helping to protect cells from oxidative damage caused by free radicals. It has been studied for its potential benefits in supporting cardiovascular health, maintaining healthy blood pressure levels, and promoting overall cellular health.
Coenzyme Q10 is available as a dietary supplement and is naturally present in various foods, with higher concentrations found in meats, fish, and oils. It is commonly used for its potential antioxidant and energy-supporting properties.
Overall, Coenzyme Q10 is an essential component of cellular energy production and also contributes to antioxidant defense, making it a subject of interest in the fields of nutrition, health, and medicine.
1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | Coenzyme Q10 |
| Synonyms: | coenzyme Q10 synthetic;Coenzyme Q10 (Water soluble);CoQ10 Ubidecarenone;Coenzyme Q10 standard;COENZYM Q10 SYNTHETIC: 99.5%;CoenzymeA/Q0/Q10A85-61-0/Q10;CoenzymeQ10Ubidecarenone;CoenzymeQ10Usp27Ep5 |
| CAS: | 303-98-0 |
| MF: | C59H90O4 |
| MW: | 863.34 |
| EINECS: | 206-147-9 |
| Product Categories: | chemical reagent;pharmaceutical intermediate;Vitamin series;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Drug bulk;Mixed Fatty Acids;Antioxidant;Benzoquinones;Biochemistry;Vitamin Related Compounds;Vitamins;Nutritional Supplements;Drugs & Medication;Fatty Acid Derivatives & Lipids;Glycerols;Steroids;Inhibitors;BENUTRI;303-98-0 |
| Mol File: | 303-98-0.mol |
| Melting point | 49-51 °C |
| Boiling point | 715.32°C (rough estimate) |
| density | 0.9145 (rough estimate) |
| refractive index | 1.4760 (estimate) |
| storage temp. | -20°C |
| form | neat |
| color | Light Orange to Dark Orange |
| Sensitive | Light Sensitive |
| Merck | 14,9843 |
| BRN | 1900141 |
| Stability: | Stable, but may be light or heat sensitive. Store in the dark at -20 C. Incompatible with strong oxidizing agents. |
| InChIKey | ACTIUHUUMQJHFO-DQXDOXBUSA-N |
| LogP | 19.119 (est) |
| CAS DataBase Reference | 303-98-0(CAS DataBase Reference) |
| EPA Substance Registry System | Ubidecarenone (303-98-0) |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-26 |
| WGK Germany | 3 |
| RTECS | DK3900000 |
| F | 8-10 |
| TSCA | Yes |
| HS Code | 29146990 |
| Toxicity | LD50 intramuscular in mouse: > 500mg/kg |
| Outline | Ubidecarenone is a small molecule lipid-soluble quinone compounds widely found in plant and animal cells, its structure is similar to the structure of vitamin K, used alone or in combination with vitamin E as a powerful antioxidant. It is required for energy generation (ATP) circulation. It promotes phosphorylation reaction and protect the structural integrity of the biofilm oxidation function. Ubidecarenone of different sources are different with its side chain prenyl units number, Ubidecarenone of humans and mammals are 10 prenyl units, thus it is called Ubidecarenone. Ubidecarenone plays an important role in proton translocation in vivo respiratory chain and electron transfer , it is the cell respiration and cell metabolism activator, and also an important antioxidant and non-specific immune enhancer. Modern biology study found that excess free radicals in the body can cause damage to the genetic material of the cell membrane, and macro manifested as aging, cancer and other symptoms. Free radical scavenging process is commonly referred to as "antioxidant." We know that life activities is driven by a variety of enzymes. Enzymes are large proteins, enzymes need some small molecules to help in exercising some functions , these substances are called "coenzyme." Ubidecarenone exists in the mitochondria within the cells. Mitochondria are the place to produce energy in cells, many enzymes and other molecules are involved in the energy production process, and Ubidecarenone is one of the indispensable one. In the organs with more energy consumption in the human body , the content of Ubidecarenone will be relatively high, such as heart, liver, kidney, kidney, spleen, pancreas, adrenal, the content is particularly rich. The total body content of Ubidecarenone is only 500-1500mg, the content changes with age, it decreased for most people after the age of 20 . Lack of Ubidecarenone are usually caused heart failure, gum disease, arrhythmias, stroke, hypertension (blood pressure, food), heart disease, arteriosclerosis, cancer, Parkinson's disease, muscular dystrophy, AIDS. Ubidecarenone can successfully prevent and treat these diseases, from 40 years ago when it was found and isolated, Ubidecarenone has been conducted hundreds of clinical studies, a lot of evidence shows that nutrition is necessary for health (health food) . |
| Discovery History | Ubidecarenone was discovered in 1957, Dr. Frederick Crane identified the chemical structure in 1958 , and received the highest honor of the American Chemical Society Priestly Medal. He is known as the father of the study of Ubidecarenone, he proposed Ubidecarenone to play an important role in heart function. In real life, Dr. Frederick Crane has been taking Q10 for 40 years, until his death at 91 years old, he had been an active energetic professors engaged in research activities. In 1978, Dr. Peter (Peter), the University of Edinburgh, Scotland, first discovered Ubidecarenone must participate in human cells energy production , and thus obtained Nobel prize. Today, Europe, Japan and other developed countries have incorporated the content of Ubidecarenone in the human body as a measure of the level of of the health of the body as an important indicator. Ubidecarenone exists in every cell of the human body, the main role is to drive the body cells to produce energy, it can accelerate cell renewal, stimulate cell activity, thus greatly promoting the cells' ability to uptake nutrients. Ubidecarenone ingredients in skin care products can effectively help the skin cells to active the absorption of other nutrients in skin care products , so skin care ingredients is no longer simply to stay on the skin surface, when reaching the underlying skin, it can quickly provide additional protecting energy for skin protection factor. If a person becomes a car for analogy, the Ubidecarenone is equivalent to the "engine", without engine, the car can not travel, without Ubidecarenone, the body can not produce the "power" to carry out daily operations. The above information is edited by the Chemicalbook of Tian Ye. |
| Biological Activity | Coenzyme Q10 (ubiquinone, ubidecarenone, coenzyme Q) is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the number of isoprenyl chemical subunits in its tail. This oil-soluble, vitamin-like substance is found in all cells as part of the electron transfer chain responsible for energy production and provides 95% of the body's energy in the form of ATP. There are three redox states of coenzyme Q10: fully oxidized (ubiquinone), semiquinone (ubisemiquinone), and fully reduced (ubiquinol). A natural resource of coenzyme Q10 is fish and shellfish although animal's foods such heart will have very high concentrations reflecting mitochondrial levels in such tissue (Crane, 2001). It has been used to reduce wrinkles (changes in the dermal matrix), reduce cell death and DNA oxidative stress, increase ATP systhesis, and suppress collagenase following UVA irradiation (Muta-Takada et al., 2009). For example, coenzyme Q10 accelerates production of basement membrane components, i.e. laminin 332 and type IV and VII collagens, in keratinocytes and fibroblasts, respectively. However, it has no effect on type I collagen production in fibroblasts. Coenzyme Q10 also shows protective effects against cell death induced by ROS in keratinocytes (Muta-Takada et al., 2009). |
| Indications | 1. the treatment of heart failure and dilated cardiomyopathy: Ubidecarenone has excellent repair effect on myocardial ischemia (hypoxia) defects caused by heart disease, and can significantly improve cardiac hypertrophy and dilated cardiomyopathy. 2. blood pressure lowering,and lipid-lowering effects: a 12-week double-blind test for 46 men and 37 female with high blood pressure found that patients whose daily consumption of 120 mg (twice) , blood pressure dropped by an average of about 17 mm Hg. 3. the antioxidant activity, application in the cardiovascular system: prevention of atherosclerosis, myocardial infarction and thrombosis, as a strong antioxidant, Ubidecarenone can resist the oxidation of LDL in the blood, reduce the formation of atherosclerosis, prevent myocardial infarction and thrombosis. 4. the treatment of congestive heart weakness: In 1970, the scientist Folkers shown that compared with the conventional drugs, daily consumption of 100 mg of Ubidecarenone for two consecutive months ,significantly improved 2/3 patient's heart function in clinical trials. 5. for post-surgical treatment of heart disease: compared with the patients who had not used Ubidecarenone, the recovery time of patients eating Ubidecarenone is greatly reduced. 6. delaying the development of heart failure, reduce mortality: Ubidecarenone can treat chest pain caused by the narrowing of coronary arteries, enhance heart beating capacity and hypoxia tolerance. 7. anti-aging and beauty: Ubidecarenone can help the skin to prevent oxidative damage to DNA, and anti-light aging, reduce wrinkles. Ubidecarenone are also commonly used in a variety of anti-wrinkle, firming and skin repair formulations. But extensive research believed that: exogenous Ubidecarenone, is far less direct and effective than the endogenous Ubidecarenone against human aging. 8. anti-fatigue: Ubidecarenone can protect and restore the integrity of the biofilm structure, it plays the membrane potential stabilizing role, it is the body's non-specific immune enhancer, and therefore exhibits excellent anti-fatigue action, maintaining the cells at a state of good health. |
| What role in the human body | Ubidecarenone has two main functions in the body, the first is playing an important role in the process of transferring nutrients into energy in the mitochondria, the second is a clear anti-lipid peroxidation effect. It is well known that free radicals generation is the the main reasons of aging. Most cells contain between 500 to 2,000 mitochondria. These mitochondrial act like a little "energy factory", transferring the food we eat into energy, thereby to maintain the operation of life. Ubidecarenone is a metabolic activator, it can activate cell respiration, accelerate the production of the energy needed by the body----adenosine triphosphate (ATP). Studies have shown that once human blood Ubidecarenone levels reduced by 25%, the body's major organs (especially the heart) will no maintain optimum operating condition because of insufficient energy. Studies have shown that antioxidants can prevent and reduce the risk of incidence of many diseases. Ubidecarenone can be synthesized in the human tissue, after age 20, the synthesis will be weakened, the liver loses the ability to synthesize Ubidecarenone, while Ubidecarenone is also difficult to obtain from the food supplement. In addition to age, bad habits, stress and infections can affect the body, resulting in not enough supply of Ubidecarenone, the body will gradually reduce the natural coenzyme in cells, which means that the body's cells gradually lose their protection. Thus accelerating the skin aging process. |
| Toxicity | Acute toxicity test in mice and rats shows the LD50 greater than 4000mg/Kg. In subacute toxicity experiments, the male and female Wistar rats were given daily 40mg, 200mg and 1000mg/Kg, sharing five weeks, male and female rabbits daily 6mg, 60mg and 600mg/Kg, continuous application of 23 days, no special finding in the test animal blood , urine test, and morphological changes. In the chronic toxicity test, the male and female Wistar rats were given daily 6mg, 60mg and 600mg/Kg 26 consecutive weeks, no special finding in the general state of the tested animals , blood and urine tests, and morphological changes. |
| Uses | 1. Coenzyme medicines. It is also an important antioxidant and immune enhancer. For congestive heart failure, arrhythmias, sinus tachycardia, premature beats, hypertension and cancer adjuvant therapy for acute and chronic viral hepatitis and subacute hepatic necrosis comprehensive treatment. In addition, it is also tested in primary and secondary aldosteronism, cerebrovascular disorders and hemorrhagic shock. during the application, user may appear nausea, upset stomach, loss of appetite and other phenomena, urticaria, and a transient palpitations occasionally appear. 2. Cardiovascular medicine. 3. It can be widely used in food, cosmetics, dietary supplements and other industries. Coenzyme drugs, is also an important antioxidant and immune enhancer. 4. It can activate human cells and cellular energy nutrition, it can improve human immunity, enhance anti-oxidation, anti-aging and enhance human activity. In addition, recent studies indicate that the product also has anti-tumor effects, for advanced metastatic cancer have a certain effect in clinical, have a significant effect in the prevention of coronary heart disease, alleviate periodontitis, treatment of duodenal and gastric ulcer, strengthen the immune system function and relieve angina . Because Ubidecarenone is effective and without side effects. It is used in pharmaceuticals, cosmetics, food additives and other industries. |
| Chemical Properties | Yellow-Orange Crystalline Powder |
| Originator | Neuquinon,Eisai,Japan,1974 |
| Occurrence | Coenzyme Q10 is found in dietary sources. Coenzyme Qmolecules have side chains of differentlengths in different types of organismsbut function in similar ways. |
| Uses | Ubidecarenone is also known as coenzyme Q10 it is a powerful antioxidant that is naturally found in the cells. It acts as a free radical neutraliser. |
| Uses | Coenzyme Q10 (CoQ10) is a naturally occurring quinone found throughout the body in cell membranes, primarily in mitochondrial membranes, with highest concentrations in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, CoQ10 acts as an antioxidant, preventing the formation of reactive oxygen species. CoQ10 deficiencies have been associated with heart failure, hypertension, parkinsonism, mitochondrial encephalomyopathies, and other chronic diseases.[Cayman Chemical] |
| Definition | ChEBI: Coenzyme Q10 is a ubiquinone having a side chain of 10 isoprenoid units. In the naturally occurring isomer, all isoprenyl double bonds are in the E- configuration. It has a role as a human metabolite, a ferroptosis inhibitor and an antioxidant. It is found in animal organs and yeast with active in the citric acid cycle in carbohydrate metabolism. |
| Therapeutic Function | UBIDECARENONE |
| General Description | Ubidecarenone, referred to as coenzyme Q, is abundantly available in human cells, with major proportions being present in vital body organs such as heart and kidneys. It plays an important role in cell metabolism owing to its significant contribution to the electron transport pathway. It is a strong antioxidant and acts as an essential enzyme catalyst in mitochondrial oxidative phosphorylation. |
| Biological Activity | Component of the mitochondrial transporter chain that behaves as a powerful antioxidant. Displays neuroprotective activity. |
| Biochem/physiol Actions | Coenzyme Q10 is an endogenous cellular antioxidant and an essential component of the electron transfer chain. CoQ10 takes part in aerobic cellular respiration and generation of energy in the form of ATP. |
| Side effects | Mild side effects might include digestive problems such as: Upper abdominal pain; Loss of appetite; Nausea and vomiting; Diarrhea. Other possible side effects may include: Headaches and dizziness; Insomnia; Fatigue; Skin itching or rashes; Irritability or agitation. |
| Purification Methods | Purify it by recrystallisation from EtOH, EtOH/Me2CO or Et2O/EtOH and by chromatography on silica gel using isoPrOH/Et2O (3:1) to give orange crystals. It has max 270nm ( 15,170) in pet ether. [Terao et al. J Org Chem 44 868 1979, NMR and MS: Naruta et al. J Org Chem 45 4097 1980, IR: Lester et al. Biochem Biophys Acta 42 1278 1959, NMR: Planta et al. Helv Chim Acta 42 1278 1959; Morton Biochemical Spectroscopy (Adam Hilger, London, 1975) p 491]. |
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