| CAS No.: | 9001-75-6 |
|---|---|
| Formula: | / |
| EINECS: | 232-629-3 |
| Environmental Protection: | No |
| Certification: | ISO9001 |
| Color: | Slightly Beige |
| Samples: |
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| Customization: |
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Hunan Yunbang Pharmaceutical Co., Ltd. (Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".1:Can I get some samples before bulk order?
A: Most products provide free samples, but the shipping cost be paid by customers.
2: What's your MOQ?
A: We can have a discussion.
3: Which kind of payment terms do you accept?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union,D/P, ETC.
4.How to place an order?
A: You can contact me through Trademanager, WhatsApp, Email and other contact methods, tell me the product and quantity you need, and then we will give you a quote.
5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.
6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
1. 90days quality guarantee for exchange.
2. For each batch order extracts, we will attach a factory Inspection Report with the goods delivery , including the BatchNo/ Date/ Test index ects; also will keep the archived extracts to ensure received by customers are the same each time.
3. Our team of experienced professionals are available online 24 hours a day to answer any questions and provide guidance on product usage and maintenance.
| Product Name: | Pepsin |
| CAS: | 9001-75-6 |
| MF: | n.a. |
| MW: | 0 |
| EINECS: | 232-629-3 |
| Product Categories: | Enzymes;API |
| Mol File: | Mol File |
| alpha | D26 -64.5° (water pH 4.6) |
| density | 1.287 g/cm3 |
| storage temp. | -20°C |
| solubility | 10 mM HCl: soluble1.0mg/mL, clear to faintly turbid, colorless |
| form | powder |
| color | slightly beige |
| Odor | Odorless |
| Water Solubility | Soluble in water and dilute aqueous buffers |
| Sensitive | Hygroscopic |
| Merck | 13,7225 |
| Stability: | Stable. Incompatible with strong bases, alkalies, metallic salts, alcohols. |
| CAS DataBase Reference | 9001-75-6 |
| EPA Substance Registry System | Pepsin A (9001-75-6) |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42-42/43 |
| Safety Statements | 22-24-26-36/37-36-45 |
| WGK Germany | 1 |
| RTECS | SC6132000 |
| F | 3-10 |
| TSCA | Yes |
| HS Code | 35079090 |
| Overview | Pepsin is a kind of endopeptidase that breaks down proteins into smaller peptides (that is, a protease). It is biologically produced in the animal stomach and is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food. Pepsin is an important acidic protease that is widely applied in the hydrolysis of proteins. It is used in collagen extraction[1-3] in gelatin extraction[4] as a rennet substitute[5] and in digestibility therapy[6]. Pepsin has been isolated and investigated from various mammals including: human, Japanese monkey, pig, bovine, goat, rat, and rabbit. Pepsin can be found primarily in the gastric juice of the stomach lumen and can be isolated from a variety of species such as human, cattles, sheeps, birds and fish[7,8]. The main location of pepsin in mammals is the stomach (both the membrane and the gastric juice) but it can also be found in limited amounts in the blood, muscle and the urine[7]. There are several types of stomach pepsins, each has a distinct protein structure and enzymatic properties[9]. Pepsin has a three-dimensional structure, of which one or more polypeptide chains twist and fold, bringing together a small number of amino acids to form the active site, or the location on the enzyme where the substrate binds and the reaction takes place. Pepsin is an aspartic protease, using a catalytic aspartate in its active site[10]. |
| Applications | Medical research Pepsin is utilized in regulation of digestion, as a dental antiseptic and in treatment of ailment including dyspepsia, gastralgia, obstinate vomiting, infantile diarrhea, apepsia and some cancer[5]. Combined with HCl, pepsin tablets and capsules have been developed to support the digestibility in the gastrointestinal tract as well as to enhance the appetite of patients [6]. Pepsin from porcine stomach is used for treatment of gastric ulcers with bismuth complexes added[7]. Pepsin is also added for better digestibility of proteins in animals feed. Pepsin is also commonly used in the preparation of F(ab')2 fragments from antibodies [23]. Cheese making Animal (calf, bovine and porcine sources) rennet is composed of pepsin and chymosin commonly mixed in a ratio of 1:9 and used in commercial cheese making. During the food manufacturing process, pepsin is very useful in: modifying and providing whipping qualities to soy protein and gelatin, modifying vegetable proteins for use in nondairy snack items, making precooked cereals into instant hot cereals, and preparing animal and vegetable protein hydrolysates for use in flavoring foods and beverages[24]. Collagen extraction Conventionally, collagen is extracted by an acid-solubilization process (ASP) in which collagen is solubilized in an acid (such as acetic acid) and other non-acid-soluble materials are removed. Since pepsin can break down cross-linkages in the telo peptide regions of collagen without harming to its secondary structure, the use of pepsin in this process can effectively enhance the yield of collagen[25]. Purification The process of partitioning of pepsin commonly involves three steps: (a) extraction of pepsinogen which involves preparation of stomach and crude extract, (b) purification of pepsinogen and (c) activation of pepsinogen to pepsin. All these steps are conducted at low temperatures (≤ 4ºC) to prevent denaturation of proteins[26]. |
| Uses | Pepsin is an enzyme that is secreted in the digestive track of mammals. It works to break down proteins into smaller peptides which can readily be absorbed by the small intestine. |
| Definition | pepsin is an enzyme that catalysesthe breakdown of proteins topolypeptides in the vertebrate stomach.It is secreted as an inactive precursor,pepsinogen. |
| Preparation | Pepsin is a stomach enzyme that serves to digest proteins found in ingested food. Production method of pepsin: using porcine gastric mucosa as raw material, after extraction with phosphate buffer solution, use DEAE-cellulose column chromatography, and after acidification, use Sephadex C-25 and Sephadex G-25 column chromatography again to refine the product. |
| General Description | Pepsin powder is prepared from the gastric mucosa of pigs, cattle or sheep. |
| Biochem/physiol Actions | Unlike many other peptidases, pepsin hydrolyzes only peptide bonds, not amide or ester linkages. The cleavage specificity includes peptides with an aromatic acid on either side of the peptide bond, especially if the other residue is also an aromatic or a dicarboxylic amino acid. Increased susceptibility to hydrolysis occurs if there is a sulfur-containing amino acid close to the peptide bond, which has an aromatic amino acid. Pepsin will also preferentially cleave at the carboxyl side of phenylalanine and leucine, and to a lesser extent at the carboxyl side of glutamic acid residues. It does not cleave at valine, alanine, or glycine linkages. Z-L-tyrosyl-L-phenylalanine, Z-L-glutamyl-L-tyrosine, or Z-L-methionyl-L-tyrosine may be used as substrates for pepsin digestion. Pepsin is inhibited by several phenylalanine-containing peptides. |
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